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This one was from the heart of a 20-year-old jujitsu fighter who was last seen at the gym and was found dead in his bed two days later. The blood vessel tissue on the slide looked abnormal. Dr. Burns turned to the examiner: “I think this was likely one of mine.”Dr. Burns is an expert in a rare childhood illness called Kawasaki disease, which is the most common cause of acquired heart disease in children worldwide. It is also one of pediatric medicine’s greatest mysteries: No one knows what causes it. And Dr. Burns, who leads the investigations at the University of California San Diego’s Kawasaki Disease Research Center, has devoted her life to solving that mystery.
Persons: Dr, Jane Burns, Burns Organizations: CSI, University of California San, Kawasaki Disease Research Locations: San Diego County
US Defense Secretary Lloyd Austin takes questions during a press conference at the Pentagon in Washington, D.C., on Feb. 1, 2024. Defense Secretary Lloyd Austin was released from the hospital Tuesday after he was admitted to a critical care unit at Walter Reed National Military Medical Center this week following hospitalization for a bladder issue. Defense Secretary Lloyd Austin was released from the hospital Tuesday after he was admitted to a critical care unit at Walter Reed National Military Medical Center this week following hospitalization for a bladder issue. The Defense Department said in a news release that Austin was released from the hospital in Washington in consultation with medical staff members at about 3:30 p.m. Austin had transferred his duties to Deputy Defense Secretary Kathleen Hicks on Sunday, the day he was hospitalized.
Persons: Lloyd Austin, Austin, Sabrina Singh, John Maddox, Walter Reed's, Gregory Chesnut, Kathleen Hicks, Hicks Organizations: US, Pentagon, Washington , D.C, Walter Reed National Military Medical, The Defense Department, NATO, Ukraine Defense Contact, Joint Chiefs, Staff, White, American, Armed Locations: Washington ,, Washington, Brussels, Ukraine
The study found military personnel stationed at U.S. Marine Corps Base Camp Lejeune were at higher risk for some types of leukemia and lymphoma and cancers of the lung, breast, throat, esophagus and thyroid. Camp Lejeune was built in a sandy pine forest along the North Carolina coast in the early 1940s. People who got sick after being at Camp Lejeune also have criticized the federal government for being slow to investigate. Frank Bove, a senior epidemiologist, has led the agency's Camp Lejeune research for many years and was in charge of the latest study. A federal law signed by President Joe Biden in August 2022 included language to address concerns of people who developed certain health problems they believe were linked to Camp Lejeune water contamination.
Persons: Camp Lejeune, Lejeune, David Savitz, , , Richard Clapp, Aaron Bernstein, Frank Bove, Clapp, Joe Biden Organizations: — Military, U.S . Marine Corps Base, Brown University, Military, Marine Corps, Agency, Toxic Substances, Centers for Disease Control, Camp Lejeune, Boston University, Lejeune, Pendleton, Battelle Memorial Institute, Camp, Associated Press Health, Science Department, Howard Hughes Medical Institute’s Science, Educational Media Group, AP Locations: Camp, Carolina, United States, U.S, Camp Lejeune, North Carolina, Atlanta
CNN —US Defense Secretary Lloyd Austin was released from Walter Reed National Military Medical Center on Monday, according to the Pentagon, two weeks after he was admitted for complications following prostate cancer surgery. Austin will work remotely “for a period of time” before returning to the Pentagon, the Pentagon statement said. His discharge comes after Austin was hospitalized on January 1 for complications from a prostate cancer procedure in December. But a little over a week later on January 1, Austin began experiencing severe pain and was taken back to the hospital in an ambulance. “The Department of Defense is the most vital element of the United States government,” Reed and Wicker said.
Persons: Lloyd Austin, Austin, , John Maddox, Gregory Chesnut, ” Austin, Biden, Joe Biden, , John Kirby, Pat Ryder, Jake Sullivan, CQ Brown, Erik Kurilla, ” Ryder, Austin’s, Walter Reed, Dr, Oliver Sartor, Otis Brawley, Sen, Jack Reed, Member Sen, Roger Wicker, ” Reed, Wicker Organizations: CNN, US, Walter Reed National Military Medical, Pentagon, Trauma, Center, Prostate Disease, Murtha Cancer, Walter Reed National Military Medical Center, House, Defense, National Security, Air Force, Joint Chiefs, Staff, US Central Command, Central Command, Cancer Disease, Mayo Clinic, Johns Hopkins Kimmel Cancer Center, Senate Armed Services, Member, Department of Defense, United, Department Locations: Iraq, Syria, Yemen, United States
WASHINGTON (AP) — Defense Secretary Lloyd Austin was released from the hospital Monday, after spending two weeks there to treat complications from surgery for prostate cancer he kept secret from senior Biden administration leaders and staff for weeks. They said he has physical therapy to do but there are no plans for further cancer treatment other than regular checks. President Joe Biden and senior administration officials were not told about Austin's hospitalization until Jan. 4, and Austin kept the cancer diagnosis secret until Jan. 9. And the White House chief of staff ordered Cabinet members to notify his office if they ever can’t perform their duties. Others openly called for Austin to resign, but the White House has said the Pentagon chief's job is safe.
Persons: Lloyd Austin, , ” Austin, Walter, Jan, John Maddox, Gregory Chesnut, Walter Reed, Joe Biden, Austin, Biden, Austin juggled, Erik Kurilla, Mike Rogers, Kathleen Hicks, lloyd, austin Organizations: WASHINGTON, , Biden, Walter Reed National Military Medical, Center, Prostate Disease, Democratic, Pentagon, U.S . Central Command, Defense Department, White, White House, Alabama Republican, House Armed Services Committee, Defense Locations: U.S, Yemen, Red
New COVID-19 Hospitalizations Increase
  + stars: | 2023-11-27 | by ( Cecelia Smith-Schoenwalder | Nov. | At P.M. | ) www.usnews.com   time to read: +1 min
Weekly COVID-19 hospitalizations increased ahead of record-breaking holiday travel, according to data from the Centers for Disease Control and Prevention. New coronavirus hospital admissions topped 18,100 the week ending in Nov. 18 – a nearly 10% increase over the week prior. Despite the increase in COVID-19 and other respiratory illnesses, the CDC reported that “hospital bed occupancy and capacity, including within intensive care units, remain stable nationally.”It’s the second week in a row that COVID-19 hospitalizations increased after mostly declining or remaining stable for about two months. Political Cartoons on the Economy View All 611 ImagesUptake of the updated COVID-19 vaccine has so far been disappointing for infectious disease researchers, with about 15% of adults rolling up their sleeves for the latest shot. While the public’s concerns over COVID-19 are surely declining as the U.S. enters its fourth holiday season with the virus, the CDC “recommends everyone 6 months and older get an updated COVID-19 vaccine to protect against the potentially serious outcomes of COVID-19 illness this fall and winter.”
Persons: Organizations: Centers for Disease Control, CDC, Federal Locations: COVID, U.S
COVID-19 vaccine uptake this fall is perhaps not what many had hoped it would be. The rates appear to be on track with the rollout of the previous updated COVID-19 shot but fall significantly short of the flu vaccine coverage so far this season. A couple other factors have probably affected vaccine uptake to a smaller extent. Smith says that it is surprising how the COVID-19 vaccination rates compare to flu shot uptake. Combination flu and COVID-19 vaccines are in the works but aren’t expected to be available to the public until 2025.
Persons: “ It's, , Camille Kotton, ” Kotton, , they've, haven’t, they're, Kotton, didn't, Emily Smith, Smith, it's, it’s Organizations: Massachusetts General Hospital, Centers for Disease Control, CDC, George Washington University Milken Institute School of Public Health, U.S . Locations: Massachusetts, COVID, U.S
CNN —Inflammation from belly fat may be linked to the early stages of Alzheimer’s disease decades before symptoms begin, new research has found. “That’s important because brain atrophy is another biomarker of Alzheimer’s disease,” Raji said. “These are people who, if they do develop Alzheimer’s disease, it won’t happen for another 20 or 25 more years. “Regardless of weight, people should find out if they have hidden visceral fat,” Raji said. Visceral fat ‘easier to lose’There’s good news: Visceral fat responds well to diet and exercise, Raji said.
Persons: , , Richard Isaacson, Isaacson, Cyrus Raji, St . Louis, ” Raji, Dr, Mahsa, Raji, ” Isaacson, It’s Organizations: CNN, Washington University School of Medicine, Radiology Society, Cleveland Clinic, Mayo Clinic Locations: Florida, St .
A sign at the front entrance to the global headquarters of Illumina is pictured in San Diego, California, U.S., November 28, 2022. REUTERS/Mike Blake/File Photo Acquire Licensing RightsCompanies Grail Inc FollowIllumina Inc FollowNov 9 (Reuters) - U.S. genetic testing Illumina (ILMN.O) on Thursday trimmed its annual profit forecast for the second straight quarter, hurt by weakness in demand for its sequencing instruments, consumables and services. Illumina also disclosed it recognized $712 million in goodwill and $109 million in intangible asset impairment related to the Grail segment, in the quarter. Illumina sees full-year adjusted profit per share to be between $0.60 and $0.70, versus its prior forecast range of $0.75 to $0.90. On an adjusted basis, the company earned 33 cents per share during the quarter, versus analysts' estimate of 12 cents per share.
Persons: Mike Blake, Illumina, Pratik Jain, Shilpi Majumdar Organizations: REUTERS, Thomson Locations: San Diego , California, U.S, China, Bengaluru
Medeloop just raised $8 million in seed funding led by General Catalyst. The startup uses AI to help speed up research tasks such as grant applications and data collection. It's working with researchers at universities in California and Canada. Caissie, who was born in Canada and previously worked as an oral and facial surgeon, wanted to build tech to solve problems he'd faced as a doctor and researcher. In 2021, he left Montreal to attend Stanford University's business school to get his MBA and build a tech platform, now known as Medeloop, that would help him conduct research quicker.
Persons: Medeloop, General Catalyst, Rene Caissie, Caissie, he'd Organizations: General, Stanford Locations: California, Canada, Montreal
Retail stores may have signs in the windows requesting that patrons wear masks, but no one inside is wearing them. Years-old stickers asking customers to stand six feet apart in line are faded, worn and ignored. The occasional storefronts in major cities advertise free Covid-19 testing, though the spaces inside are empty. And the virus is still disrupting work, school and politics: A Covid outbreak tied to a City Council meeting in Nashville this month left more than a dozen people infected, including council members, city employees and at least one reporter. “I haven’t really had to think about the phrase ‘superspreader event’ in a long time.”
Persons: , we’ve, , Michael T, Freddie O’Connell, hasn’t, ” Mr, O’Connell Organizations: Infectious Disease, University of Minnesota Locations: Nashville
Ten milligram tablets of the hyperactivity drug, Adderall, made by Shire Plc. Adderall and alternative ADHD medications apart from other drugs are Schedule 2 controlled substances. Production limitationsEnding the shortages of Adderall and other ADHD medications is no easy task. That means increasing the production of one drug could potentially require reducing production — and potentially impacting supply — of another drug, according to Ergun. That includes Aytu BioPharma, which makes an ADHD drug that used to be in shortage.
Persons: Jb Reed, It's, Erin Fox, they've, David Margraf, Margraf, drugmakers, Ozlem Ergun, Ergun, Novartis's, Michael Ganio, ASHP's Ganio, RJ Sangosti, Josh Disbrow, Fox Organizations: Shire Plc, Jb, Bloomberg, Getty, and Drug Administration, CNBC, University of Utah, American Society of Health, System Pharmacists, Centers for Disease Control, University of Minnesota's, Infectious Disease, Northeastern University, Teva Pharmaceuticals, Amneal Pharmaceuticals, Sandoz, Purdue Pharma, Rhodes Pharmaceuticals, Drug, Fox, Pharmacists, Drug Enforcement Administration, MediaNews, Denver, FDA, DEA Locations: U.S, Commerce City , Colorado
The company told Reuters that 49% of Black volunteers did not meet the trial's amyloid threshold requirements compared to 22% for whites and 55% for Hispanics. "Is it because MCI (mild cognitive impairment) or early dementia type-symptoms in Blacks are caused by other reasons more so than Alzheimer's?" In 96 dementia trials from 2000-2017, diverse populations only made up around 11% of enrollment, according to a 2018 study. Among Black people who died of Alzheimer's, their dementia was more likely to result from multiple causes, such as vascular disease. "Is it that it's not Alzheimer's disease?
Persons: Barrington, Vickie Riley, Charlie, Harriet Shaffer, Barrington Riley, , Eli Lilly, Lilly, Crystal Glover, Eisai, Ivan Cheung, Cheung, Shobha, Biogen, Mark Mintun, Alzheimer's, Dr Lisa Barnes, Barnes, Joshua Grill, we're, Reisa Sperling, Brigham, Julie Steenhuysen, Caroline Humer, Suzanne Goldenberg, Daniel Flynn Organizations: Emory University Brain Health, Americans, Reuters, Prospective Black, Rush, Disease Research, and Drug Administration, FDA, Black, MCI, National Institutes of Health, Rush Center, University of California, Women's Hospital, Thomson Locations: Atlanta , Georgia, U.S, Chicago, Tokyo, Irvine, United States
July 19 (Reuters) - The president of Stanford University, one of the most prestigious U.S. schools, announced plans on Wednesday to resign his post after an independent review ordered by its board of trustees found flaws in his research as a neuroscientist. Those allegations were in connection with Alzheimer's disease research carried out when Tessier-Lavigne was the executive vice president of research drug discovery at the U.S. biotechnology company Genentech Inc. But the review of 12 research papers dating over two decades found that when concerns about the research were raised, "Tessier-Lavigne failed to decisively and forthrightly correct mistakes in the scientific record." As a result of the review, Tessier-Lavigne said he was going to retract three papers and correct another two. The board of trustees named Richard Saller, a professor in Stanford's Department of Classics, as interim president beginning Sept. 1.
Persons: Marc Tessier, Lavigne, Tessier, " Tessier, Richard Saller, Brad Brooks, Will Dunham, Donna Bryson Organizations: Stanford University, Stanford, University, Genentech Inc, Stanford's Department of Classics, Thomson Locations: U.S, Palo Alto , California, Lubbock , Texas
CNN —Results are in from the highly anticipated clinical trial on the Mediterranean-DASH Diet Intervention for Neurodegenerative Delay or MIND diet — a diet designed specifically to boost the brain — and they are less stellar than anticipated. Actually, the MIND diet did improve the brains of those who followed it for three years. Past studies have shown both the MIND diet and the Mediterranean diet significantly reduced the risk of cognitive decline and Alzheimer’s disease. The MIND diet also assimilates elements of the Dietary Approaches to Stop Hypertension (or DASH) diet. The DASH diet has been shown to reduce blood pressure and is the American Heart Association’s top diet.
Persons: , Lisa Barnes, Barnes, Walter Willett, Harvard T.H, Willett, “ It’s, David Katz, ” Katz, romaine, ” Willett, , Katz Organizations: CNN, Disease Research, Rush University Medical Center, Harvard, of Public Health, Harvard Medical School, True Health Initiative, Rush University, New, of Medicine, Blue Locations: Chicago, Chan, Amsterdam, American, Swiss chard
Lilly expects the U.S. Food and Drug Administration to decide by the end of this year whether to approve donanemab. The company had previously reported that 24% of the overall donanemab treatment group had brain swelling. The deaths of three trial patients were linked to the treatment, researchers reported. For high tau patients, donanemab was shown to slow disease progression by about 17%, while the benefit was 35% for those with low-to-intermediate tau levels. Both medications are also being studied in large trials to see if they have an impact on delaying onset of Alzheimer's disease symptoms.
Persons: Seth Gale, Brian Snyder, Eli Lilly, Anne White, Lilly, Susan Kohlhaas, Liana Apostolova, White, Liz Coulthard, donanemab, Deena Beasley, Ludwig Burger, Will Dunham, Bill Berkrot, Caroline Humer Organizations: Alzheimer Research, Brigham, Women’s, REUTERS, Alzheimer's Association International, U.S . Food, Drug Administration, Alzheimer’s Research, Indiana University School of Medicine, Doctors, University of Bristol, JAMA, FDA, Alzheimer's Association, Health Organization, New York Stock Exchange, Thomson Locations: Boston , Massachusetts, U.S, Amsterdam, Eisai
If the sleep apnea is severe and untreated, people have three times the risk of dying from any cause. People with severe sleep apnea who spent less time in deep, also known as slow-wave sleep, had more damage to the white matter of the brain than people who had more slow-wave sleep, according to the study. “The association with sleep apnea was only unveiled when we isolated severe cases, suggesting that mild to moderate sleep apnea may not be significantly associated with white matter changes,” he said. About 34% of the participants had mild sleep apnea, 32% had moderate and 34% had severe sleep apnea. People with sleep apnea, however, can have dozens of micro-awakenings during the night as they snore, snort or gasp for breath.
The drug manufacturer Eli Lilly announced on Wednesday that a clinical trial of an experimental Alzheimer’s drug showed it can slow progress of the feared disease and allow patients to have more time when they can still live independently, performing tasks like cooking meals, going to the store and driving a car. Lilly announced its results, from a trial involving 1,736 patients, in a news release, as required by the Securities and Exchange Commission. The drug, donanemab, is not a cure, but along with two other drugs recently approved by the Food and Drug Administration,it may be a turning point in the long and frustrating quest to find an Alzheimer’s treatment. “These all point in the same direction,” said Dr. Ronald Petersen, the director of the Alzheimer’s Disease Research Center at the Mayo Clinic. He added that the donanemab results were “modest” but “meaningful.” “
But time spent waiting robs early patients of their memory and ability to live independently. This condition is often, though not always, a sign of early Alzheimer's disease. PET scans cumbersomeTwo types of tests can diagnosis Alzheimer's disease: PET scans and spinal taps. Early Alzheimer's disease can also be diagnosed with a spinal tap, in which fluid around the spinal cord is extracted with a catheter and tested. He believes big players like CVS will provide infusions for Alzheimer's disease on a major scale if they see there's a large and stable market.
The platform will draw on data from medical records, insurance claims, pharmacies, mobile devices, sensors and various government agencies, they said. The database could help identify healthy people at risk for Alzheimer's, which affects about 6 million Americans, for future drug trials. The U.S. Medicare health plan for older adults will likely require such tracking in a registry as a condition of reimbursement for Leqembi. Silverberg said the data platform could also help researchers working in other disease areas understand which patients are most at risk and the impact of medications. The system would be built in a secure computing environment with a number of restrictions to ensure the privacy of people's health data, Silverberg said.
“We’re looking a lot for potential early warning signs in the medical supply chain for any kinds of disruptions,” said an administration official. “One major concern throughout the entire pandemic has been that because of China’s zero Covid policy, shutdowns greatly reduced manufacturing capacity in China. Despite efforts over the past two years by the Biden administration to bolster the country’s domestic medical supply chain, the complexity, costs and regulations involved in health care manufacturing has limited companies’ ability to shift production. I think that would be a natural response,” said Douglas Kent, executive vice president of corporate and strategic alliances at the Association for Supply Chain Management. Health care officials say they hope that the U.S. is in a better place to withstand any shocks from China.
The U.S. officially recorded more than 100 million cases as of Tuesday, just under one-third of the total population, according to data from the Centers for Disease Control and Prevention. Covid-19 has easily infected more than 200 million in the U.S. alone since the beginning of the pandemic — some people more than once. "There are have been at least 200 million infections in the U.S., so this is a small portion of them," Frieden said. The estimate was based on a survey of commercial lab data that found about 58% of Americans had antibodies as a result of a Covid infection. The more than 21 million additional confirmed cases on top of the CDC's February estimate of about 187 million total infections gives a low-end estimate of more than 208 million infections since the pandemic began.
[1/2] People line up at a makeshift fever clinic set up inside a stadium, amid the coronavirus disease (COVID-19) outbreak in Beijing, China December 19, 2022. "We stand ready to help any country in the world with vaccines, treatments, anything else that we can be helpful with," he said. "We want China to get COVID right," Blinken said earlier this month. “China faces a very challenging system in reopening,” Powell said, adding that its manufacturing, exporting and supply chain remain critical. Officials set up health centers and apps that told people with symptoms how to avoid infecting others, he said.
Even when demand is not sky-high, drugs shortages happen regularly – but usually more quietly – in the US. At any time, the reasons why shelves may be empty vary from place to place and from drug to drug. With children’s medications, drug manufacturers say they are running full-tilt, and they planned for some increase in sales over the winter months. The FDA tracks drug shortages too, taking reports directly from manufacturers, but it defines them differently than the pharmacists’ group. The White House says drug shortages are a priority for President Biden’s administration, too.
The intended beneficiaries of the taxpayer-fueled Presidential Election Campaign Fund — presidential candidates — don't want it, as they're soured by its restrictions on their election fundraising and spending. An accounting of the Presidential Election Campaign Fund, as of October 31, 2022. Several nonprofit leaders told Insider that Congress could use the Presidential Election Campaign Fund money to immediately ease suffering, particularly in light of the COVID-19 pandemic. During the 2019-20 congressional session, two Republican lawmakers sponsored similar bills that attempted to kill the Presidential Election Campaign Fund. Until that or any other repurposing decision comes down, the FEC continues to spend taxpayer resources keeping the Presidential Election Campaign Fund alive.
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